Neutron research in the fight against viral diseases: Covid-19, AIDS, Influenza and others

Influenza and SANS: Large-Scale Conformational Dynamics Control H5N1 Influenza Polymerase PB2 Binding to Importin α
J. Am. Chem. Soc. 2015, 137, 48, 15122-15134
https://doi.org/10.1021/jacs.5b07765

Combined results from solution studies on intact influenza virus M1 protein and from a new crystal form of its N-terminal domain show that M1 is an elongated monomer
Arzt S., Baudin F., Barge A., Timmins P.A., Burmeister W.P., Ruigrok R.W.H. Virology 279, 439-446 (2001)
https://doi.org/10.1006/viro.2000.0727

Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles

Arteta MY, Kjellman T, Bartesaghi S, Wallin S, Wu X, Kvist AJ, Dabkowska A, Székely N, Radulescu A, Bergenholtz J, Lindfors L. PNAS (2018) 115(15): E3351–E3360; https://pubmed.ncbi.nlm.nih.gov/29588418/

Investigation of charge ratio variation in mRNA – DEAE-dextran polyplex delivery systems

C. Siewert, H. Haas, T. Nawroth, A. Ziller, S.S. Nogueira, M.A. Schroer, C.E. Blanchet, D.I. Svergun, A. Radulescu, F. Bates, Y. Huesemann, M.P. Radsak, U. Sahin, P. Langguth. Biomaterials 192 (2019) 612–620; https://doi.org/10.1016/j.biomaterials.2018.10.

ESS Data Scientist helps shed light on assembly mechanism of hepatitis B virus, ESS website
Ryan C. Oliver, Wojciech Potrzebowski, Seyed Morteza Najibi, Martin Nors Pedersen, Lise Arleth, Najet Mahmoudi, and Ingemar André. "Assembly of Capsids from Hepatitis B Virus Core Protein Progresses through Highly Populated Intermediates in the Presence and Absence of RNA". ACS Nano 2020, 14, 8, 10226–10238.
https://doi.org/10.1021/acsnano.0c03569

Coupling neutron reflectivity with cell-free protein synthesis to probe membrane protein structure in supported bilayers
Soranzo, T., Martin, D.K., Lenormand, J. et al. Coupling neutron reflectivity with cell-free protein synthesis to probe membrane protein structure in supported bilayers. Sci Rep 7, 3399 (2017).
https://doi.org/10.1038/s41598-017-03472-8

Neutrons reveal hidden secrets of the hepatitis C virus
https://www.ill.eu/news-press-events/press-corner/press-releases/neutrons-reveal-hidden-secrets-of-the-hepatitis-c-virus/

Intrinsic disorder in measles virus nucleocapsids
Jensen M.R., Communie G., Ribeiro Jr E.A., Martinez N., Desfosses A., Salmon L., Mollica L., Gabel F., Jamin M., Longhi S., Ruigrok R.W., Blackledge M. Proceedings of the National Academy of Sciences of the USA 108, 9839-9844 (2011)
https://doi.org/10.1073/pnas.1103270108

Fusion of raft-like lipid bilayers operated by a membranotropic domain of the HSV-type I glycoprotein gH occurs through a cholesterol-dependent mechanism
Giuseppe Vitiello, Annarita Falanga, Ariel Alcides Petruk, Antonello Merlino, Giovanna Fragneto, Luigi Paduano, Stefania Galdiero, Gerardino D’Errico. Soft Matter 02/2015.
https://doi.org/10.1039/C4SM02769H

Cholesterol modulates the fusogenic activity of a membranotropic domain of the FIV glycoprotein gp36
Giuseppe Vitiello, Giovanna Fragneto, Ariel Alcides Petruk, Annarita Falanga, Stefania Galdiero, Anna Maria D ‘ursi, Antonello Merlino, Gerardino D Errico. Soft Matter 2013.
https://doi.org/10.1039/C3SM50553G

Destabilization of Lipid Membranes by a Peptide Derived from Glycoprotein gp36 of Feline Immunodeficiency Virus: A Combined Molecular Dynamics/Experimental Study
A. Merlino, G. Vitiello, M. Grimaldi, F. Sica, E. Busi, R. Basosi, A. M. D’Ursi, G. Fragneto, L. Paduano, and G. D’Errico
J. Phys. Chem. B, 2012, 116 (1), pp 401–412
https://doi.org/10.1021/jp204781a

Ensemble structure of the highly flexible complex formed between vesicular stomatitis virus unassembled nucleoprotein and its phosphoprotein chaperone
Yabukarski F., Leyrat C., Martinez N., Communie G., Ivanov I., Ribeiro E.A., Buisson M., Gérard F.C., Bourhis J.M., Jensen M.R., Bernadó P., Blackledge M., Jamin M. Journal of Molecular Biology 428, 2671-2694 (2016)
https://doi.org/10.1016/j.jmb.2016.04.010