Understanding the enhanced mRNA functional delivery of lipid nanoparticles formulated using a high-throughput platform

Image credit: Science Photo Library

Biopharmaceutical company, AstraZeneca, recently developed an automated technique to generate lipid nanoparticles for mRNA delivery and used neutron scattering to investigate how it compared to standard production methods.

The challenge

During the development of a connected surgical clamp, CareTag needed to assess the integrity of the encapsulation surrounding an electronic device (Fig 1). The company used X-ray imaging to investigate their product but a full assessment of gluing integrity between the polymer and steel parts was not possible.

The experiment

CareTag was advised on the use of neutron tomography to complement X-ray imaging. When the steel surgical clamp was scanned on a neutron imaging beamline, bubble-like structures were identified on the radiographic and tomographic images (Fig 2).

The results

The measurements confirmed that a quantitative evaluation of the number and size of the pores is feasible despite the presence of a high X-ray- and neutron-absorbing material within the electronics.

"The information provided by the neutron scan gave significant insight into the glue of the RFID-tag. We are pleased to see that there are no defects or irregularities between the metal and the chip, suggesting that the current adhesive procedure is satisfactory. We were delighted to be given the opportunity to use this advanced characterisation technique, and we hope we can return to perform a comparative test of another process.”

Søren Bilsøe
Co-founder of CareTag Surgical